Understanding Population-based Migraine through Genome-wide Genetics

Dan Chasman, Harvard University, Boston, MA

In spite of recent advances in treatment, migraine remains among the top-ranked conditions in the burden of disability globally, especially among women. The prospect of additional migraine treatments is limited by sparse knowledge of fundamental underlying pathophysiologic mechanisms. Recently, genome-wide genetic approaches to migraine in the population are revealing biological functions relevant to migraine, providing insights into its clinical correlates, and addressing the underlying heterogeneity intrinsic to migraine’s clinical presentation